Experimental neurologyAnimalsIsofluraneMiceCullin ProteinsMale
Cullin-1 silencing ameliorates isoflurane-induced cognitive impairment via inhibition of PHLPP1 degradation in adult mice.
Chang Ye, Yue Qian, Chaochao Chen, Yulin Huang, Binwen Liu, Liangyu Peng, Zhengliang Ma, Xiaoping Gu, Tianjiao Xia
Published: 202610.1016/j.expneurol.2025.115505
Abstract
Long-term or repeated anesthesia has been shown to potentially contribute to cognitive dysfunction. Existing animal studies have demonstrated that long-term anesthesia using inhaled anesthetics, such as isoflurane, may impact cognitive performance vi…
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