Experimental gerontologyAnimalsOsteoclastsHepcidinsFemaleCell Differentiation
Hepcidin inhibits osteoclast differentiation to alleviate osteoporosis by modulating the p53/miR-34a/Trem2 axis.
Lujun Chen, Guiwen Liu, Sheng Liu, Yin Zhu, Zhongrui Liu, Luliang Wei, Yuzhen Liao, Yongjun Ye, Weimin Huang, Wuyang Liu, Lulin Liu
Published: 202610.1016/j.exger.2025.112994
Abstract
BACKGROUND: The relationship between iron accumulation and osteoporosis (OP) progression has received attention in recent years. Hepcidin is a key regulator of iron homeostasis and may contribute to the treatment of OP. However, the underlying molecu…
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