European urology
MLH1 Mismatch Repair Deficiency Predicts Exceptional Response to Immune Checkpoint Inhibition in Clear-cell Renal Cell Carcinoma.
Mark T Dawidek, Lina Posada Calderon, Parantu K Shah, Rohan Mittal, Burcin Agridag Ucpinar, Ziad Bakouny, Kevin Meli, Eddy Saad, Renée-Maria Saliby, H Jun Woo, Yash S Khandwala, Marc Eid, Chris Labaki, Marc Machaalani, Jonathan Coleman
Published: 202510.1016/j.eururo.2025.09.4162
Abstract
Immune checkpoint inhibition can result in deep and durable responses in clear-cell renal cell carcinoma (ccRCC), yet no biomarkers currently guide management. While mismatch repair (MMR) deficiency is an established predictive biomarker for immunoth…
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