European urology oncology
Germline DNA Repair and Immune-metabolic Alterations Suggest a Potentially Distinct Form of Early-onset Prostate Cancer in Men of African Descent.
Jean-Samuel Loger, Emeline Colomba, Alexis Vallard, Mylène Annonay, Sarah Malsa, Taina Labeau, Sylviane Ulric-Gervaise, Sabrina Pennont, Ainara Martin-Martinez, Mickaelle Rose, Odile Béra, Sylvie Merle, Celine Minchaca, Johan Rose-Dite-Modestine, Régine Marlin
Published: 202510.1016/j.euo.2025.11.015
Abstract
BACKGROUND AND OBJECTIVE: Early-onset prostate cancer (PCa) is more frequent in men of African descent; yet, the biological mechanisms underlying susceptibility remain unclear. While most germline studies have focused on DNA repair genes (DRGs), alte…
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