European urology oncologyHumansMaleProstatic NeoplasmsCastration-ResistantPhthalazines
Talazoparib Monotherapy in Metastatic Castration-resistant Prostate Cancer with DNA Damage Response Alterations-Genomic Features Associated with Response to Therapy.
Karim Fizazi, Johann S de Bono, A Douglas Laird, Philippe Barthélémy, Rémy Delva, Tanya Dorff, Marco Maruzzo, Adam Stirling, Jean-Pascal Machiels, Herlinde Dumez, Vincent Renard, Julia F Hopkins, Lee A Albacker, Hsiang-Chun Chen, Cynthia G Healy
Published: 202510.1016/j.euo.2025.09.016
Abstract
BACKGROUND AND OBJECTIVE: The impact of alterations beyond DNA damage response-homologous recombination repair (DDR-HRR) genes on outcomes with poly(ADP-ribose) polymerase inhibitor monotherapy remains unknown. This study aims to explore the impact o…
Preview only. Read the full abstract at the source