Environmental toxicology and pharmacology
N-acetylcysteine reduces incidence and duration of linezolid-associated thrombocytopenia in critically ill patients: A randomized controlled trial.
Mohamed Abdeltawab, Abdel-Hameed Ebid, Osama Ahmed, Mohamed A Mobarez, Mahmoud Ibrahim
Published: 202610.1016/j.etap.2026.104944
Abstract
Linezolid-associated thrombocytopenia (LAT) limits its use in critically ill patients. This double-blind, randomized, placebo-controlled trial evaluated intravenous N-acetylcysteine (IV NAC) for LAT prevention in 250 critically ill adults receiving l…
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