Histopathological and toxicogenomic evaluation of 1,4-dioxane toxicity after a 14-day repeated oral administration.

1,4-dioxane (DON) has been widely used as a pharmaceutical ingredient, a solvent in organic synthesis reactions, and a stabilizer in chlorinated organic solvents. Although DON shows hepatocarcinogenicity in mice and rats, the mode of action has not f…

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