Enzyme and microbial technologyCatechinMethylationSubstrate SpecificityMethyltransferasesBacillus licheniformis
Mutational study-based identification of high activity O-methyltransferase for the regioselective methylation of epigallocatechin gallate.
Gyeongguk Park, Byung-Gee Kim, Joo-Hyun Seo
Published: 202610.1016/j.enzmictec.2025.110779
Abstract
The site-specific methylation of (-)-epigallocatechin-3-O-gallate (EGCG), especially 3`` hydroxyl group in D-ring, significantly enhances its stability and bioavailability in human body. Therefore, the methylation is the way to make EGCG more orally…
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