Enzyme and microbial technologyAcyltransferasesDipeptidesMolecular Dynamics SimulationBacillusEnzyme Stability
Enhanced synthesis of alanyl-glutamine dipeptide via molecular modification and process optimization of α-amino acid ester acyltransferase EAET.
Jinao Wei, Xiaoxi Liu, Yifei Gao, Jing-Wen Yang, Hong-Bin Zhang, Xue-Qin Hu
Published: 202610.1016/j.enzmictec.2025.110754
Abstract
This study presents a significant advancement in the enzymatic synthesis of alanyl-glutamine (Ala-Gln) through the development of a high-performance α-ester acyltransferase (EAET) using molecular engineering. We successfully cloned EAET from Bacillus…
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