European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical SciencesBlood-Brain BarrierAnimalsDexamethasoneAcyclovirAntiviral Agents
Effect of different doses of dexamethasone on the penetration of acyclovir across the blood-brain barrier.
Jiahua Zhao, Yuheng Shan, Yuying Cen, Mengyao Wang, Tiantian Zhuang, Yibing Li, Yuxuan Liu, Zhiyong Nie, Jianwei Xie, Jiatang Zhang
Published: 202610.1016/j.ejps.2025.107378
Abstract
Acyclovir (ACV) is a widely used antiviral agent for the treatment of herpes simplex virus encephalitis. Dexamethasone (DEX) is often co-administered as an adjunctive therapy. Tariquidar (TQD), a potent and selective inhibitor of P-glycoprotein, has…
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