European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical SciencesAnimalsMidazolamCytochrome P-450 CYP3AMaleOrganic Anion Transporters
Drug transporter - enzyme crossroads: Does OATP2B1 shape Cyp3a-driven midazolam metabolism in rats?
Nikolaos Paloumpis, Marta Rysz, Noemi Bianchi, Isabell Seibert, Jonny Kinzi, Anima M Schäfer, Karin Brecht, Daniel Ricklin, Henriette E Meyer Zu Schwabedissen
Published: 202510.1016/j.ejps.2025.107343
Abstract
OATP2B1, encoded by SLCO2B1, is an uptake transporter in liver. Humanized SLCO2B1+/+ rats showed increased hepatic Cyp3a1 expression compared to rSlco2b1-/- rats. To assess the impact of humanization on Cyp3a activity, we conducted a phenotyping stud…
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