European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical SciencesHumansATP Binding Cassette TransporterSubfamily GMember 2Carcinoma
The fourth-generation EGFR tyrosine kinase inhibitor BLU-945 resensitizes ABCG2-overexpressing multidrug-resistant non-small cell lung cancer cells to cytotoxic anticancer drugs.
Yen-Ching Li, Bing-Huan Lin, Megumi Murakami, Yu-Shan Wu, Tai-Ho Hung, Suresh V Ambudkar, Chung-Pu Wu
Published: 202510.1016/j.ejps.2025.107337
Abstract
ABCG2, a key ATP-binding cassette (ABC) transporter, contributes significantly to multidrug resistance (MDR) by actively effluxing a wide range of chemotherapeutic agents from cancer cells, thereby lowering intracellular drug concentrations and reduc…
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