European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical SciencesSolubilityCarbon DioxidePharmaceutical PreparationsAlgorithmsMachine Learning
High-fidelity prediction of drug solubility in supercritical CO₂ for pharmaceutical applications using advanced computational modeling.
Hashem O Alsaab, Saeed Shirazian
Published: 202510.1016/j.ejps.2025.107321
Abstract
Accurately estimating the solubility of drugs in supercritical carbon dioxide (SCCO₂) still represents a major difficulty in drug formulation, separation processes, and green technologies. Traditional empirical and semi-empirical methods usually have…
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