European journal of pharmacology
Reprogramming lysosomal-purinergic crosstalk governs the synergistic attenuation of NLRP3 inflammasome activation by cyclodextrin-P2X7 blockade in diabetic rats.
Elsayed A Elmorsy, Manal Mohamed Hatem, Hamad Alsaykhan, Abdulaziz A Alsalloom, Mostafa M Khodeir, Mohammed Alorini, Rabab S Hamad, Alshaimaa A Farrag, Mohamed A M Ali, Norah Suliman Alsoqih, Omar Almansour, Mariam S Alharbi, Ahmad H Alhowail, Hesham Saad Ata, Basem H Elesawy
Published: 202610.1016/j.ejphar.2026.178602
Abstract
Steatohepatitis links cholesterol-crystal injury to ATP-gated purinergic signaling, culminating in NF-κB/NLRP3 inflammasome activation and metabolic dysfunction. We posited that dissolving cholesterol burden while concurrently blocking P2X7 would rep…
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