European journal of pharmacology
Bufotalin Targets COL1A1 to Suppress Non-Small Cell Lung Cancer Growth and Remodel the Tumor Microenvironment via Dual Inhibition of PI3K/AKT/mTOR and MAPK Pathways.
Yuxiu Zhang, Panpan Lei, Jinna Liang, Sifan Xie, Xiaoyu Ma, Weina Ma
Published: 202610.1016/j.ejphar.2026.178601
Abstract
Non-small cell lung cancer (NSCLC) remains the leading contributor to cancer mortality, and its relentless progression is partly fueled by the overexpression of α1-type I collagen (COL1A1), an extracellular-matrix protein whose abundance herald disma…
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