European journal of pharmacology
Glycyrrhetinic acid ameliorates cholestatic liver injury by inhibiting acHMGB1/TLR2-mediated crosstalk between hepatocytes and macrophages.
Fengyi Weng, Bin Zou, Jing Zhao, Jiamin Cui, Fengling Li, Dongming Yan, Xiaoqing Xu, Shuang Zhang, Yue Li, Jingyi Jin, Furong Qiu
Published: 202610.1016/j.ejphar.2026.178595
Abstract
The crosstalk between hepatocytes and macrophages is a key mechanism driving the pathogenesis of cholestatic liver injury (CLI). Glycyrrhetinic acid (GA), a bioactive compound derived from licorice, offers protection against CLI, but its effect on he…
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