European journal of pharmacology
4-Phenylbutyrate attenuates doxorubicin-induced cardiorenal comorbidity by suppressing ER stress-mediated epithelial-mesenchymal transition and endothelial-mesenchymal transition.
Wenyu Hui, Weiwei Cui, Jie Li, Mengyuan Cheng, Yangyang Liu, Yunru Peng, Yongfang Ding
Published: 202610.1016/j.ejphar.2026.178580
Abstract
OBJECTIVE: Cardiorenal syndrome (CRS), a spectrum of disorders involving intertwined cardiac and renal dysfunction, poses a significant challenge to mechanistic research due to a lack of accurate in vivo models. This study investigated the role of en…
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