European journal of pharmacology
Sevoflurane postconditioning mitigates cognitive impairment induced by hemorrhagic shock resuscitation through inhibition of METTL3-mediated m6A modification of Sirt1 mRNA.
Yujie Wu, Zhilun Niu, Shoufeng Zhu, Wenli Huang, Jianan Wang, Wenhui Tao, Bingqian Fan, Li Zhang, Xianwen Hu
Published: 202610.1016/j.ejphar.2026.178578
Abstract
Hemorrhagic shock resuscitation (HSR) induces cognitive impairment. Sevoflurane postconditioning (SPC) exerts neuroprotection, partially via Sirt1 activation. N6-methyladenosine (m6A), a crucial eukaryotic mRNA modification regulated by methyltransfe…
Preview only. Read the full abstract at the source