European journal of pharmacologyAnimalsNLR FamilyPyrin Domain-Containing 3 ProteinAtherosclerosisMice
Schisandrol B alleviates the progression of atherosclerosis by inhibiting the NLRP3-pyroptosis signaling axis driven by M1-type macrophage polarization.
Ning Liu, Shuang Zhao, Yuhan Ao, Jianan Su, Zimeng Liu, Pingxi Zhou, Shuwen Pang, Jing Li
Published: 202610.1016/j.ejphar.2026.178552
Abstract
Atherosclerosis (AS) is a major underlying cause of cardiovascular diseases, with hypercholesterolemia, inflammatory responses, and macrophage polarization being established key contributors. The roles of NLRP3 inflammasome activation and macrophage…
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