European journal of pharmacologyAnimalsHistamine N-MethyltransferaseHistamineMiceWakefulness
Histamine N-methyltransferase inhibition as a novel therapeutic strategy for idiopathic hypersomnia.
Birkan Girgin, Fumito Naganuma, Kyosuke Hirano, Motoki Fujiya, Toshimasa Mimura, Ren Ebina, Ruoyu Zhu, Ayaka Nishibe, Tadaho Nakamura, Ramalingam Vetrivelan, Chika Miyoshi, Takatoshi Mochizuki, Hiromasa Funato, Masahiko Watanabe, Masashi Yanagisawa
Published: 202610.1016/j.ejphar.2025.178475
Abstract
Idiopathic hypersomnia (IH) is a sleep disorder characterised by excessive daytime sleepiness despite adequate night-time sleep. Although current treatments, including low-sodium oxybate and modafinil, are readily available for IH, they are associate…
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