European journal of pharmacologyReceptorsGABA-AEtomidateHumansAnimals
Nezavist (DCUK-OEt) and aminoquinoline analogues interact with the etomidate site and display a complex mode of modulatory action of the GABAA receptor.
Xenia Simeone, Sophia Khom, Angelika Maria Doppler, Thomas Seidel, Petra Scholze, Boris Tabakoff, Margot Ernst
Published: 202610.1016/j.ejphar.2025.178464
Abstract
The aminoquinoline compound Nezavist (DCUK-OEt; ethyl 5,7-dichloro-4-(3,3-diphenylureido)quinoline-2-carboxylate) is under preclinical and early clinical investigation for chronic pain, alcohol use disorder (AUD), and relapse prevention in nicotine d…
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