European journal of pharmacologyHumansCarcinomaNon-Small-Cell LungLung NeoplasmsGlycogen Synthase Kinase 3 beta
AMT inhibits the progression of non-small cell lung cancer by suppressing the PI3K/AKT/GSK-3β/β-catenin pathway via H3K27me3 regulation.
Yixing Gao, Guoji E, Lan Feng, Ping Gan, Shirui Huang, Ziyi Tang, Qian Liang, Yan Wang, Yuqi Gao, Erlong Zhang
Published: 202610.1016/j.ejphar.2025.178460
Abstract
Reprogramming of glycine metabolism is closely associated with cancer initiation and progression. The mRNA and protein expression of aminomethyltransferase (AMT), an enzyme of the glycine cleavage system, is decreased in human non-small cell lung can…
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