European journal of pharmacologyAnimalsOleic AcidsObesityRenal InsufficiencyChronic
Uncovering the pleiotropic effects of oleoylethanolamide on obesity-driven chronic kidney disease in mice.
Federica Comella, Stefania Melini, Nicola Opallo, Evaristo Di Napoli, Nicole Pia Navatti, Orlando Paciello, Maria Carmela Ferrante, Rosaria Meli, Giuseppina Mattace Raso, Claudio Pirozzi
Published: 202610.1016/j.ejphar.2025.178436
Abstract
Metabolic alterations, resulting from obesity, drive chronic kidney disease (CKD) through mechanisms including lipotoxicity, inflammation, and fibrosis. Oleoylethanolamide (OEA), an endogenous compound belonging to the N-acylethanolamine family, has…
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