European journal of pharmacologyFerroptosisAnimalsBenzamidesAminopyridinesIdiopathic Pulmonary Fibrosis
Roflumilast mitigates idiopathic pulmonary fibrosis via inhibition of iron accumulation and ferroptosis.
Liting Feng, Shuangyu Han, Yajing Li, Siyu Zhan, Li Li, Yubao Wang, Jing Feng
Published: 202510.1016/j.ejphar.2025.178385
Abstract
OBJECTIVE: To investigate roflumilast's anti-fibrotic effects in idiopathic pulmonary fibrosis (IPF) and its role in suppressing ferroptosis. METHODS: This study utilized bleomycin (BLM) -induced murine IPF and transforming growth factor beta 1 (TGF-…
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