European journal of pharmacologyAnimalsBerberineMitochondriaMiceCardiolipins
Berberine rescues PANoptosis-Driven hemophagocytic lymphohistiocytosis via cardiolipin-mediated mitochondrial stabilization.
Amany I Almars, Reem Hasaballah Alhasani, Ifat Alsharif, Aishah E Albalawi, Fahad Eid Albalawi, Mohammad H Alhashmi, Wajnat A Tounsi, Nahlah M Ghouth, Waheeb S Aggad, Zuhair M Mohammedsaleh, Hailah M Almohaimeed, Tabinda Hasan, Mona H Soliman
Published: 202610.1016/j.ejphar.2025.178384
Abstract
Pyroptosis, apoptosis, and necroptosis can converge through a unified inflammatory cell death pathway termed PANoptosis, which plays a pivotal role in the pathogenesis of diverse inflammatory disorders. The isoquinoline alkaloid berberine (BBR) is kn…
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