European journal of pharmacologyAnimalsEncephalomyelitisAutoimmuneExperimentalAlkaloids
Oxymatrine regulates microglia to produce IFN-β by activating the STING/TBK1/IRF3 pathway against experimental autoimmune encephalomyelitis.
Shuang-Shuang Wang, Xin Jin, Wen-di Ma, Wen-Ying Li, Meng-Meng Dou, Tong-Yin Yan, Nan Liu, Chong Liu, Xiao-Yu Zhao, Ming-Liang Zhang, Lin Zhu, Yao-Juan Chu
Published: 202510.1016/j.ejphar.2025.178380
Abstract
Oxymatrine is an alkaloid with the property of immunomodulation. Recent studies have demonstrated that oxymatrine inhibits experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS), by promoting the production of int…
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