European journal of pharmacologyAnimalsDexmedetomidineToll-Like Receptor 4Brain-Derived Neurotrophic FactorProto-Oncogene Proteins c-akt
Unlocking dexmedetomidine's therapeutic potential in multiple sclerosis: Dual modulation of PI3K/Akt/BDNF and TLR4/NF-κB pathways in EAE rats.
Mohamed A Salem, Mostafa A Rabie, Nabila N El Maraghy, Yasmin A M El-Said, Nesrine S El Sayed, Suzan M Mansour
Published: 202510.1016/j.ejphar.2025.178365
Abstract
Multiple sclerosis (MS) is an enduring autoimmune and neurodegenerative disease affecting the central nervous system with inflammation, demyelination, and axonal degeneration that progresses to neurological impairment. Despite available treatments, t…
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