European journal of pharmacologyAnimalsDopamineMethyl-CpG-Binding Protein 2ReceptorsDopamine D1
Ghrelin restores D1 receptor-mediated dopamine neurotransmission and enhances attentive behaviour in Mecp2 KO mice.
Yukie Kawahara, Yoshinori N Ohnishi, Tomoyuki Takahashi, Yuki Kishikawa, Mahomi Kuroiwa, Kotaro Yuge, Hiroshi Kawahara, Yushiro Yamashita, Toyojiro Matsuishi, Akinori Nishi
Published: 202510.1016/j.ejphar.2025.178352
Abstract
Rett syndrome is an X-linked neurodevelopmental disorder characterised by cognitive, attentional, and communicative impairments along with sensory and motor deficits. Optimal activation of dopamine D1 receptor signalling in the prefrontal cortex (PFC…
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