European journal of pharmacologyHumansReactive Oxygen SpeciesApoptosisProto-Oncogene Proteins c-aktPrecursor T-Cell Lymphoblastic Leukemia-Lymphoma
Selective induction of apoptosis in T-cell acute lymphoblastic leukemia by pristimerin through dual PI3K/AKT pathway inhibition and ROS generation.
Shilpa Kuttikrishnan, Zahwa Mariyam, Fareed Ahmad, Mohammad Suleman, Ummu Habeeba, Anu J Panicker, Kirti S Prabhu, Maysaloun Merhi, Said Dermime, Ammira S Al Shabeeb Akil, Ajaz A Bhat, Abdul W Ansari, Shahab Uddin
Published: 202510.1016/j.ejphar.2025.178329
Abstract
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy characterized by the aberrant activation of survival pathways, particularly the PI3K/AKT axis. Pristimerin (Prist), a naturally occurring quinonemethide triterpenoi…
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