European journal of pharmacologyAnimalsGlycocalyxLysophospholipidsSphingosineGlucuronidase
Sphingosine-1-phosphate protects against sepsis-associated encephalopathy by suppressing heparanase-mediated endothelial glycocalyx degradation.
Ling Tang, Baojun Liang, Yuchen Zhang, Junjie Li, Yi Feng, Jiarong Huang, Xing Li, Jiajia Zhu
Published: 202510.1016/j.ejphar.2025.178305
Abstract
Sepsis-associated encephalopathy (SAE) is a severe complication of sepsis, frequently accompanied by disruption of the blood-brain barrier (BBB), neuroinflammation, and cerebral edema. The endothelial glycocalyx, an essential component of the BBB, is…
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