European journal of pharmacologyAnimalsFemalePregnancySeizuresPentylenetetrazole
Brain-targeted intranasal pregabalin niosomes for the treatment and prevention of teratogenic congenital malformations in PTZ-induced seizures in pregnant rats without passing placental barrier.
Assmaa Gaber, HebatAllah H Mahmoud, Ossama M Sayed, Zienab E Eldin, Ahmed A G El-Shahawy, Fatma I Abo El-Ela
Published: 202510.1016/j.ejphar.2025.178279
Abstract
The study evaluated the efficacy of a niosomal formulation of pregabalin (PGB) in pentylenetetrazole (PTZ)-induced seizures in pregnant rats with acute epileptic-type convulsions. The rats were divided into five groups: (1) a saline-administered nega…
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