European journal of pharmacologyAnimalsBrain-Derived Neurotrophic FactorSchizophreniaProto-Oncogene Proteins c-aktSignal Transduction
Quercetin exerts neuroprotective effects through activation of PI3K/AKT/CREB/BDNF signaling pathway in double blow model-induced schizophrenia-like mice.
Yating Yang, Mengdie Li, Yunxiao Liu, Bei Luo, Menglin Ge, Kai Zhang, Huanzhong Liu, Hongbo He
Published: 202510.1016/j.ejphar.2025.178272
Abstract
OBJECTIVE: Cognitive impairment represents a core clinical feature of schizophrenia, yet effective therapeutic interventions remain lacking. Given quercetin's demonstrated anti-inflammatory and neuroprotective properties, this study investigates its…
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