European journal of pharmacologyAnimalsProtein Serine-Threonine KinasesTransforming Growth Factor beta1FibrosisSignal Transduction
Amlexanox alleviates renal inflammation and fibrosis by inhibiting cGAS/STING/TBK1 and TGF-β1/Smad signaling.
Shobhit Gairola, Ravinder K Kaundal
Published: 202510.1016/j.ejphar.2025.178266
Abstract
BACKGROUND: The cGAS/STING/TBK1 signaling is a key regulator of the renal innate immune response, driving sterile inflammation and fibrosis. This study explores the therapeutic efficacy of amlexanox (AMX), a TANK-binding kinase 1 (TBK1) inhibitor, in…
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