European journal of pharmacologyAnimalsMethylphenidateOxidation-ReductionBehaviorAnimal
Chronic methylphenidate abuse: Effects on behaviour, redox homeostasis, and cholinergic system.
Natália Freddo, Jéssica Nardi, Wagner Antonio Tamagno, Suelen Mendonça Soares, Milena Fortuna, Amanda Carolina Cole Varela, Lisiane Siqueira, Aline Pompermaier, Luciane do Prado, Nicole Berton, Francieli Ubirajara India Amaral, Ana Paula de Oliveira, Inara Carbonera Biazus, Leonardo José Gil Barcellos, Luciana Grazziotin Rossato-Grando
Published: 202610.1016/j.ejphar.2025.178259
Abstract
Methylphenidate (MPH) (metil 2-fenil-2-(piperidin-2-il) acetato) is used as a drug of abuse as well as a cognitive enhancer owing to its amphetaminic structure. The objective of this study was to evaluate whether chronic exposure to an abusive contex…
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