European journal of pharmacologyHumansElongation Factor 2 KinaseAnimalsCardiovascular DiseasesMolecular Targeted Therapy
Pharmacologic targeting of eEF2K in cardiovascular diseases: Mechanisms and potential clinical applications.
Aysa Rezabakhsh, Solomon Habtemariam, Elnaz Khani, Batool Ghorbani Yekta, Raha Rahmani, Hadis Iraji, Seyed Mohammad Nabavi
Published: 202510.1016/j.ejphar.2025.178253
Abstract
Eukaryotic elongation factor 2 kinase (eEF2K) is a calcium/calmodulin-dependent enzyme that regulates protein synthesis by phosphorylating eukaryotic elongation factor 2 (eEF2). Activation of eEF2K under stress conditions such as nutrient deprivation…
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