European journal of pharmacologyAnimalsMaleReperfusion InjurySignal TransductionProto-Oncogene Proteins c-akt
Acute calcitriol treatment alleviates cerebral ischemia reperfusion injury via activation of MasR/PI3K/Akt/CREB axis and suppression of AT-1R/NF-κB p65 signaling cascade.
Doaa Abd El-Tawab, Mostafa A Rabie, Reham A Mohamed, Mohammed F El-Yamany
Published: 202510.1016/j.ejphar.2025.178240
Abstract
Global cerebral ischemia-reperfusion (IR) injury often follows cardiac arrest and resuscitation, leading to severe neurological impairment. Calcitriol (CAL) has shown neuroprotective potential, but its acute effects and underlying mechanisms in IR in…
Preview only. Read the full abstract at the source