European journal of pharmacologyAnimalsFluorouracilAnemiaMiceDeoxyadenosines
Cordycepin deteriorates 5' fluorouracil-induced anaemia by AMPK activation.
Lei Yang, Siqi Kong, Hailan Shi, Liangyu Xu, Zichen Wei, Yafeng Chen, Lei Fang
Published: 202510.1016/j.ejphar.2025.178232
Abstract
Cordycepin (COR) is a compound extracted from Cordyceps sinensis. We found that COR exacerbates the acute anaemia induced by 5' fluorouracil (5-FU). Healthy mice were intraperitoneally injected with COR at doses of 2, 4, or 8 mg/kg for 10 consecutive…
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