European journal of pharmacologyAnimalsPregnanoloneEncephalomyelitisAutoimmuneExperimental
Neuroprotective role of allopregnanolone in alleviating depression-like behaviors by modulating brain function in experimental autoimmune encephalomyelitis model.
Shujia Song, Tao Wang, Linwen Liu, Boru Yuan, Afang Zhu, Yuyan Yang, Xue Zhang, Chao Ma, Lijian Pei, Yuguang Huang
Published: 202510.1016/j.ejphar.2025.178222
Abstract
BACKGROUND: Depression is among the most common comorbidities associated with MS, significantly impairing patients' quality of life and prognosis. In this study, we investigated the therapeutic effects of allopregnanolone (AP) on depression-like beha…
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