European journal of pharmacologyHumansHippo Signaling PathwayInduced Pluripotent Stem CellsHematopoietic Stem CellsSignal Transduction
A pyrimido-indole derivative promotes the differentiation of hematopoietic stem and progenitor cells from human-induced pluripotent stem cells by modulating YAP/Hippo signaling pathway.
Palida Saleepimol, Gorawin Chaiyakitpattana, Benjamin Ongnok, Pongpon Phuwakanjana, Tanida Chokpanuwat, Phaewa Chaiwijit, Veeravat Changkeb, Klodthida Yanukun, Nontaphat Thongsin, Methichit Wattanapanitch, Nithi Asavapanumas, Alisa Tubsuwan, Nareerat Sutjarit, Suradej Hongeng, Kanit Bhukhai
Published: 202510.1016/j.ejphar.2025.178208
Abstract
Hematopoietic stem and progenitor cell (HSPC) therapy effectively treats hematological disorders, such as hemoglobinopathies, aplastic anemia, and leukemias. However, limited HSPC availability and loss of stemness restrict clinical application, neces…
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