European journal of pharmacologyDiabetic NephropathiesHumansHydroquinonesVascular Endothelial Growth Factor ABaculoviral IAP Repeat-Containing 3 Protein
Integration of transcriptomics, machine learning, and molecular simulations identifies key microvascular-protective genes VEGFA and BIRC3 mediated by tert-butylhydroquinone in diabetic kidney disease treatment.
Anlei Yuan, Zewen Wang, Yanxia Liu, Yue Ren, Lulu Zheng, Beiyan Li, Zhaozhou Lin, Yanling Zhang
Published: 202510.1016/j.ejphar.2025.178207
Abstract
Diabetic kidney disease (DKD) is a microvascular complication of diabetes that can progress to renal failure. Tert-butylhydroquinone (TBHQ) exhibits renal protective effects in type II diabetes, but its regulatory role on microvascular protection-rel…
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