European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.VKetoconazoleBiological AvailabilityHumansSuccinic AcidSolubility
Enhancing bioavailability of a weakly basic drug through cocrystallization: PBPK modeling of ketoconazole-succinic acid.
Ana Karolina Santos Goes, Amira Soliman, Venkata Krishna Kowthavarapu, Paulo Renato Oliveira, Natalia Valadares de Moraes
Published: 202610.1016/j.ejpb.2026.114986
Abstract
Pharmaceutical cocrystals, formed by combining an active pharmaceutical ingredient (API) with a suitable coformer, offer a promising strategy to enhance drug solubility, stability, and dissolution, thereby improving absorption and bioavailability wit…
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