European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.VHydrogelsHumansBreast NeoplasmsFemaleTriazoles
Tuna Collagen-Based hydrogels for the targeted delivery of BET inhibitors and BET-PROTACs in breast cancer therapy.
Irene Sevilla-Carrillo, Carolina Hermida-Merino, Inmaculada Posadas, Martin Kreuzer, María Del Mar Noblejas-López, Alberto Ocaña, Jesús Valcárcel, Daniel Hermida-Merino, Manuel M Piñeiro, Carlos Alonso-Moreno, Iván Bravo
Published: 202510.1016/j.ejpb.2025.114898
Abstract
Targeted protein degradation (TPD) strategies, including BET inhibitors and PROTACs, offer a promising approach for cancer therapy by selectively degrading disease-relevant proteins. However, their clinical translation is hindered by poor solubility,…
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