European journal of medicinal chemistry
Dual / bifunctional targeting of bromodomain and extra-terminal (BET) proteins: Expanding the paradigm of epigenetic drug discovery.
Fei Jiang, Huili Li, Quan Sun, Jiandong Huang, Xianggui Chen, Qian Liang, Xueyuan Luo, Wenbao Zhang, Dandan He, Xiangchun Shen
Published: 202510.1016/j.ejmech.2025.118524
Abstract
Bromodomain and extra-terminal (BET) proteins function as key epigenetic regulators of oncogenic, inflammation, and immune pathways, however, their therapeutic targeting has been constrained by limitations of monofunctional inhibitors-notably compens…
Preview only. Read the full abstract at the source