European journal of medicinal chemistryStructure-Activity RelationshipLeishmania infantumHumansAntiprotozoal AgentsPyridines
Discovery of antileishmanial hits in the 3-nitroimidazo[1,2-a]pyridine series via newly optimized tetrakis(dimethylamino)ethylene (TDAE) methodology at position 2.
Inès Jacquet, Romain Paoli-Lombardo, Caroline Castera-Ducros, Hugo Pomares, Sandra Bourgeade-Delmas, Patrice Vanelle, Nicolas Primas
Published: 202610.1016/j.ejmech.2025.118506
Abstract
To explore the antileishmanial structure-activity relationships at position 2 of the 3-nitroimida-zo[1,2-a]pyridine scaffold, we developed a new synthetic method using Tetrakis(dimethylamino)ethylene (TDAE) and N-tosylbenzylimines. This original synt…
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