European journal of medicinal chemistryHexokinaseHumansBenzothiazolesAntineoplastic AgentsDrug Design
Combinatorial library design approach identifies a novel benzothiazole-based hexokinase 2 inhibitor with anti-tumor efficacy in oral squamous cell carcinoma.
Purbali Chakraborty, Shouvik Bhuin, Syeda Lubna, Ashna Fathima, K Deepika, Pruthvi Gudipati, Manab Chakravarty, Trinath Jamma, Perumal Yogeeswari
Published: 202610.1016/j.ejmech.2025.118483
Abstract
Hexokinase 2 (HK2), a pivotal enzyme in glycolysis, is frequently overexpressed in oral squamous cell carcinoma (OSCC), contributing to tumor proliferation, survival, and metabolic adaptation. Targeting HK2 offers a promising therapeutic strategy due…
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