European journal of medicinal chemistryLysosomesAnimalsGlucagon-Like Peptide 1HumansMice
Development of glucagon-like Peptide-1 lysosomal targeting chimeras for degradation of extracellular and membrane proteins.
Liquan Zhu, Haotian Liu, Xin Zeng, Ke Liu, Xiaozhen Liu, Zhuotao Yang, Yuchen Duan, Da Qian, Chaoqi He, Xuli Meng
Published: 202610.1016/j.ejmech.2025.118473
Abstract
Lysosome-targeting chimeras (LYTAC) represent a revolutionary technology for targeted protein degradation. However, the scarcity of highly efficient lysosomal transport receptors poses a major bottleneck to LYTAC advancement. In previous studies, we…
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