European journal of medicinal chemistryAlzheimer DiseaseAmyloid beta-PeptidesAnimalsCholinesterase InhibitorsStructure-Activity Relationship
Benzylpiperidine-pyridazin-3(2H)-one derivatives as potential multifunctional agents against Alzheimer's disease.
Yichun Shi, Heng Zhang, Shiqin Cong, Xingyu Zhu, Yao Liu, Jinjin Li, Ke Tang, Rong Xue, Xiuxiu Liu, Zhenghuai Tan, Junli Chen, Yong Deng
Published: 202610.1016/j.ejmech.2025.118437
Abstract
Based on multitarget-directed-ligands (MTDLs) strategy, a series of benzylpiperidine-pyridazin-3(2H)-ones were designed, synthesized and evaluated as innovative multifunctional agents for Alzheimer's disease (AD). Biological evaluation revealed that…
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