European journal of medicinal chemistrySARS-CoV-2Coronavirus 3C ProteasesKetonesHumansAntiviral Agents
Thiazolyl 4-carboxylate ketone as a new warhead for a highly potent SARS-CoV-2 main protease inhibitor.
Maria A Theodoropoulou, Haifa El Kilani, Christiana Mantzourani, Dirk Jochmans, Johan Neyts, Kaixuan Zhang, Judith Röske, Maroula G Kokotou, Rolf Hilgenfeld, George Kokotos
Published: 202610.1016/j.ejmech.2025.118436
Abstract
The SARS-CoV-2 main protease (Mpro), an enzyme essential for viral replication and lacking a human homologue, has emerged as a highly attractive target for the development of novel antiviral agents. Although several Mpro inhibitors have been develope…
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