European journal of medicinal chemistryHumansGlutamate Carboxypeptidase IIHeterocyclic Compounds1-RingChelating Agents
A series of conjugates based on prostate-specific membrane antigen ligands with the chelating agent DOTA: synthesis, radiolabeling, and biological activity.
N S Butakova, A A Uspenskaia, N Y Zyk, S A Petrov, K A Popovicheva, A S Lunev, K A Petrosova, I A Mitrofanov, M N Ivashkovskaya, S A Evteev, Y A Ivanenkov, E K Beloglazkina, A A Larenkov, A E Machulkin
Published: 202610.1016/j.ejmech.2025.118433
Abstract
Prostate-specific membrane antigen (PSMA) is a crucial zinc-containing metalloprotease that belongs to the type II transmembrane protein family, also known as glutamate carboxypeptidase II (GCPII). PSMA stands out as a highly promising target for the…
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