European journal of medicinal chemistryAnimalsDrug DesignRatsNitric Oxide Synthase Type IINeuroprotective Agents
Design, synthesis, and biological evaluation of hybrids from both nitrones with eNOS-mimicking activity and selective iNOS inhibitors for the treatment of ischemic stroke.
Weijie Jiao, Hui Ye, Duorui Ji, Mengshuang Huang, Ruichen Li, Jian Jia, Bowen Wang, Shurui Wang, Zhen Lei, Nan Qin, Hong Wu, Xiaokun Li, Guiyue Wu, Yinglin Cui, Yihua Zhang
Published: 202610.1016/j.ejmech.2025.118428
Abstract
Ischemic stroke (IS) involves complex pathologies such as excitotoxicity, oxidative stress, and inflammation. Targeting inducible nitric oxide synthase (iNOS) which produces damaging levels of NO, while sparing neuroprotective endothelial NOS (eNOS)…
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